NEUROFIBROMATOSIS ASSOCIATED DIFFUSE CYSTIC LUNG DISEASE

Neuro?bromatosis is an autosomal dominant disorder of neuroectodermal and mesenchymal origin, also known as Von Rechlinghausen disorder. It can also occur inherited or sporadically. A mutation of NF1 gene on chromosome 17q11.2 has been recognized as a disease prompter, and the spectrum of clinical phenotype is wide because of gene complexity, size and diversity of exons. In our article we are presenting a case of neuro?bromatosis associated with diffuse cystic lung disease.

Calcifying Aponeurotic Fibroma in the left pectoral region in an adult: A Case report.

Calcified aponeurotic fibroma is a rare benign fibroblastic tumor. The lesion has property of local invasion and high recurrence. Because of this property, tumor should be accurately diagnosed pre-operatively. We report a case of 29 years old male, with a palpable painful mass on the anterior chest wall near left pectoral region, describes radiographic and MR findings. No skin defect was detected but patient feels discomfort. An excision procedure was done. The excised tissue was sent for biopsy and calcified aponeurotic fibroma was diagnosed

Correlation between D-dimer and HRCT in Covid-19

Background: To retrospectively determine the correlation between CTseverity score & D-dimer. Methodology: This is retrospective original research of 227 patients (IPD & OPD) during April 1 to May 31, 2021 for Covid-19. Patients CTseverity scores, HRCTThorax findings, D-dimer, Platelet count and Demographic variables were recorded. The correlation between CTseverity score & D-dimer were determined. Results:Between the mentioned dates, 227 patients are taken into study which includes 146 Males & 81 Females. Mean of CTseverity score was 6.7, D-dimer was 0.46mg/l. Higher CTscore is seen in males (mean -7.1) as compare to females (mean -6.12). D-dimer are seen higher in males (mean =0.52mg/l) as compare to females (median=0.37mg/l). The study of 227 patients has shown positive correlation between CTscore & D-dimer (r=0.38, p<0.05). Males showed relatively stronger positive correlation (r=0.4, p<0 .05) than females (r=0.3, p<0.05). Patients with age less than equal to 45 has shown relatively stronger positive correlation between CTscore & D-dimer (r=0.4, p<0.05) than patients with age more than 45 (r=0.35, p<0.05). Conclusion:Pulmonary lesion induced by SARS-CoV-2 infection was associated with raised inflammatory response, impairment in exchange of gases, and end organ damage. In study, we can conclude that lung lesion may exert important role in COVID-19 pathogenesis & clinical presentation